The City of Santa Rosa (In Tagalog, Lungsod ng Santa Rosa) is a 1st class city in the province of Laguna, Philippines. It is also known as "The Investment Capital of South Luzon" since 1994. The city lies 38 kilometers south of Manila via the South Luzon Expressway, making it a suburban residential community of Metro Manila. This quiet town of Laguna started its progress initially from the establishment of Filsyn, CIGI and couple of other small multinational companies there when the government BOI provided for incentives to companies located at not less than 40 kilometers away from Manila. According to the 2007 census, City of Santa Rosa has a population of 266,943 inhabitants (185,633 people in 43,625 households in census 2000) but in 2005, it surpassed San Pablo City in terms of population, making it the fourth largest town or city in Laguna after Calamba City, San Pedro and Biñan.

Ford Motor Company has a plant here, assembling the Ford Lynx, Ford Focus, Mazda 3, Ford Escape, and Mazda Tribute and also selling Ford Ranger, Ford Everest & Mazda6. Other automobile manufacturers that have plants in Santa Rosa City include Nissan Motors Co., Ltd., Toyota Motor Corporation, Honda Motor Co., Ltd., Isuzu Motors Ltd. (now in Binan), and Mitsubishi. Also, the location of the plant of Monde Nissin Corporation is also in Santa Rosa, particularly in Barangay Balibago.

City of Santa Rosa is also the location for the largest plant of The Coca-Cola Company in the Philippines, which is situated right across the Santa Rosa Exit of the South Luzon Expressway.

Santa Rosa is the 2nd municipality/city in Southern Luzon to have both an SM and Robinsons after Dasmarinas in Cavite

Santa Rosa became a city by virtue of Republic Act No. 9264, which was ratified by the citizens on July 10, 2004.